Beilstein Journal of Organic Chemistry, vol: 15, (2019)
Two new aromatic polyketides from a sponge-derived Fusarium
Sibero M.T., Zhou T., Fukaya K., Urabe D., Karna Radjasa O.K., Sabdono A., Trianto A., Igarashi Y.
Abstract
In our natural product screening program from marine fungi, two new aromatic polyketides karimunones A (1) and B (2) and five known compounds (3–7) were isolated from sponge-associated Fusarium sp. KJMT.FP.4.3 which was collected from an Indonesian sponge Xestospongia sp. The structures of these compounds were determined by the analysis of NMR and MS spectroscopic data. The NMR assignment of 1 was assisted by DFT-based theoretical chemical shift calculation. Compound 2 showed antibacterial activity against multidrug resistant Salmonella enterica ser. Typhi with a MIC of 125 µg/mL while 1 was not active. © 2019 Sibero et al.
Keyword: Aromatic polyketide; Fusarium; Marine fungus; Secondary metabolite; Sponge