AACL Bioflux, vol: 13,2 (2020)
Coral-associated fungi as a natural inhibitor for treatment of multidrug-resistant pathogens
Cristianawati O., Sabdaningsih A., Nuryadi H., Sabdono A., Trianto A., Radjasa O.K.
Abstract
Researches on bioactive compounds from hard coral-associated fungi (HCAF) in Indonesia have been less documented than bacterial associated part. This is especially promising when it comes to find a solution to the problem of antibiotic-resistant bacteria. This study’s aim was to determine the inhibitory potential of HCAF against several selected pathogenic bacterial strains. The discovery of novel bioactive compounds generally involves three major steps. The first step is the isolation of hard coral samples in an appropriate media, followed by an antimicrobial assay of an HCAF against various microbial pathogens, and lastly the identification of potential microbes. Assay values for the compounds were determined against the following multidrug-resistant (MDR) bacteria, namely Staphylococcus haemolyticus, Staphylococcus aureus, Pseudomonas aeruginosa, Klebsiella pneumoniae, Enterobacter aerogenes, Acinetobacter baumannii, Enterobacter cloacea complex and Escherichia coli. This study successfully identified HCAF as having potential as an antibacterial compound. Inhibitory activity on the growth of mentioned MDR was visible on 18 out of 38 fungi. As a result, the potential of these novel antibacterial agents with activity against MDR bacteria is highlighted. The study of HCAF can serve as a powerful strategy for the discovery of novel antibiotics against human pathogens. © 2020, BIOFLUX SRL. All rights reserved.
Keyword: Antibiotic-resistant bacteria; Inhibitory activity; Marine derived-fungi; Marine invertebrate