IOP Conference Series: Earth and Environmental Science, vol: 55,1 (2017)
Study on Anticancer Activity of Extracts of Sponges Collected from Biak Water, Indonesia
Trianto A., Ridhlo A., Triningsih D.W., Tanaka J.
Abstract
Indonesia is center of biodiversity where marine sponges are abundant. a source of bioactive compounds with various pharmaceutical properties such as anticancer, antifungal, antibacterial, antioxidants, anti-inflammatory, and anti-malarial. In a continuation of a search for biologically active molecules from marine organisms we investigated the potency of marine sponges as anticancer. A total of 106 sponge specimens were collected between 3-40 m depths by SCUBA diving in Biak waters during August 2005. The specimens were extracted with methanol to provided crude extracts. The methanolic extracts were tested against NBT-T2 cell line. The assay result showed that 8.5 %, 29.2 % and 46.2 % of the extract have activity against the cell line at 0.1, 1.0 and 10.0 μg/mL. While, a 16.0 % of the extract did not showed activity against the cell line. © Published under licence by IOP Publishing Ltd.
Keyword: anti-cancer; extract; NBT-T2; screening; sponge