Marine Drugs, vol: 3,3 (2005)
Polycitorols A and B, new tricyclic alkaloids from an ascidian
Issa H.H., Tanaka J., Rachmat R., Setiawan A., Trianto A., Higa T.
Abstract
Two new tricyclic alkaloids, polycitorols A (1) and B (2) have been isolated along with the known lepadiformine (3) from a marine ascidian of the family Polycitoridae. The structures of the new compounds were elucidated by analysis of NMR data and comparison with those of 3 and other related compounds [1-5]. Compounds 1 and 2 are closely related to cylindricines A and B, lacking C-4 oxygenation found in cylindricines and having a butyl instead of a hexyl appendage. NOE experiments on compounds 1 and 2 suggested the A/B ring fusion to be cis. © 2005 by MDPI.
Keyword: Ascidian; Polycitoridae; Polycitorols; Polycyclic alkaloids; Tricyclic alkaloids